Cancer Suppression Treatments at Angeles Health

We recognize that a disease does not appear ‘over night’, but rather that the dysfunction of disease is the result of lifelong interactions between our environment and our genetic predispositions.

Returning a patient to health requires reversing or substantially improving the specific dysfunctions that have contributed to the disease state. Each patient therefore represents a unique, complex, and interwoven set of influences and intrinsic functionality that have set the stage for the development of disease, as well as the maintenance and restoration of health.

Our approach to cancer suppression is defined by four main pillars:

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  1. Systemic Hyperthermia
  2. Autologous immune enhancement therapy
    1. Dendritic cells
    2. NK cells
  3. T-cell modulating therapy
  4. Synergistic cancer suppressors

 

Hyperthermia

Most of us have experienced the positive effects of a hot bath on aching muscles, or the balm of holiday sun on an English winter body. Heat just feels good.

We use heat for healing in many ways – for instance a hot water bottle on the tummy for period pains or a microwave-heated wheat-pack on stiff and aching neck muscles. From time immemorial we have benefited from sweating – from Turkish baths to the saunas in modern spas. The Egyptians treated tumors with heat back in 5,000 BC, and the principles of tumor-heating are now widely understood – that heat stimulates the tissue temperature, causing the body to react by dilating blood vessels, so that tissues get revitalized due to the improved circulation. One of the main principles of traditional Chinese medicine is that good circulation promotes health.

Way up at the other end of the scale is medically-supervised whole-body and localized hyperthermia. A much bigger gun altogether.

What are the different methods of hyperthermia?

Several methods of hyperthermia are currently under use being local, regional and systemic perfusion the most common ones.

Local Hyperthermia Treatment

In local hyperthermia, heat is applied to a small area, such as a tumor, using various techniques that deliver energy to heat the tumor. Different types of energy may be used to apply heat, including microwave, radiofrequency, and ultrasound. Depending on the tumor location, there are several approaches to local hyperthermia:

External approaches are used to treat tumors that are in or just below the skin. External applicators are positioned around or near the appropriate region, and energy is focused on the tumor to raise its temperature.

Intraluminal or endocavitary methods may be used to treat tumors within or near body cavities, such as the esophagus or rectum. Probes are placed inside the cavity and inserted into the tumor to deliver energy and heat the area directly.

Regional Hyperthermia Treatment 

In regional hyperthermia, various approaches may be used to heat large areas of tissue, such as a body cavity, organ, or limb.

Deep tissue approaches may be used to treat cancers within the body, such as cervical or bladder cancer. External applicators are positioned around the body cavity or organ to be treated, and microwave or radiofrequency energy is focused on the area to raise its temperature.

Regional perfusion techniques can be used to treat cancers in the arms and legs, such as melanoma, or cancer in some organs, such as the liver or lung. In this procedure, some of the patient’s blood is removed, heated, and then pumped (perfused) back into the limb or organ. Anticancer drugs are commonly given during this treatment.

 Systemic Perfusion Hyperthermia

All hyperthermia methods involve the transfer of heat into the body from an external heat source . While heat absorption from these sources results in a highly non-uniform distribution of the thermal energy, the Systemic Perfusion Hyperthermia method used at Angeles Hospital, allows the phycisians to control the exact goal temperature, and quickly results in a uniform temperature distribution throughout the whole body.

Indeed, systemic hyperthermia is the only way to achieve uniform heating of tissues due to the ability to control physiological mechanisms of thermoregulation , such as sweating, vasodilation counteracting attempts to increase body temperature.

In Systemic Perfusion Hyperthermia technique, blood is extracted in a constant flow and heated up to 42oC by the Systemic Perfusion System.

Before returning to the body, the hyper-heated blood passes through a detoxification filter to cleanse it of toxins and cellular debris.

Throughout the procedure the patient is monitored by trained staff and by the Systemic Perfusion Hyperthermia System at all times.

Hyperthermia’s effects on Cancer

The principle is that cancer cells react more sensitively to the effects of excessive heat than normal cells. Also, tumors have an impaired ability to adapt their blood circulation to the effects of high temperatures and thus hyperthermia can cause a reduction of blood flow to a tumor. In addition, heat at this level pushes cancer cells toward acidosis (decreased cellular pH) which decreases the cells´ viability and ability to spread. It also activates the immune system, causing both increased production of interferon alpha, and increased immune surveillance.

Tumor masses tend to have oxygen deprived (hypoxic) cells within the inner part of the tumor.

Benefits Systemic Perfusion Hyperthermia Non-Systemic Hyperthermia
Continuous treatment for up to 4 hours YES NO
Creates a burning sensation NO YES
Destruction of Cancer cells through Thermotherapy YES YES
Destroys cancer cells by targeting its anaerobic condition YES NO
Balance and Stimulation of the immune System YES YES
Lowers Inflammation YES YES
Destroys Virus, Bacteria and Fungi YES NO
Removes plaque build-up in Blood Vessels YES NO
Removes Heavy Metals YES NO
Repairs Tissues YES NO
Promotes Homeostasis YES NO
Detox/cleanses the blood from toxins YES NO
Precise Control of whole Body Temperature YES NO
Induce Apoptosis YES YES
Inhibit Angiogenesis YES YES

Hyperthermia and Cancer

The combination of immunotherapy with hyperthermia for treating cancer, however, is a particularly intriguing notion, as significant clinical effects of hyperthermia have been attributed to the immune system. The accepted view of the cancer-host immune interface is that tumors possess unique antigens that can be recognized by the immune system. After antigen uptake at tumor sites, APCs have the ability to create a robust response by entering lymphoid compartments and programming lymphocytes. Following generation and expansion to large numbers, cytotoxic lymphocytes then traffic to tumor sites for targeted cell killing.

adaptiveTumorImmunity

To understand how temperature may influence the immune system, it is necessary to define the concept of hyperthermia. As the father of clinical thermometry, Wunderlich is credited with defining normal body temperatures at 37°C and describing a dynamic range of normal body temperatures with diurnal variations. Fever induces the elevation of the physiological set point of body temperature, increasing core body temperatures via specific thermo-effectors. Hyperthermia differs fundamentally from fever in that it elevates the core body temperature without changing the physiological set point.

Hyperthermia-induced Hsps as modulators of the immune system

Cellular functions of Hsps

Hsps were discovered in 1962 as a result of the accidental application of thermal stress to Drosophila preparations.

Hsps are a family of stress-induced proteins with several critical cellular functions, and are typically designated by their molecular weight.

Hsps are recognized as central mediators of a variety of cellular functions under physiological conditions, as they are key regulators of cellular protein activity, turnover and trafficking.

Hsps in cancer

Hsps are present in an abundance of tumor types and may function to confer several survival benefits to cancer cells.

There is evidence that a specific Hsp, Hsp70, directly inhibits apoptosis pathways in cancer cells. The synthesis and accumulation of Hsps in tumor cells exposed to hyperthermia afford protection from further heat-associated cytotoxic events, as the Hsps rescue or restore vital cellular proteins.

There is evidence that Hsps support the malignant phenotype of cancer cells by not only affecting the cells’ survival, but also participating in angiogenesis, invasion, metastasis and immortalization mechanisms. Contrary to the many benefits conferred upon tumor cells expressing high levels of Hsps, tumor cell dependence upon Hsps for several critical functions represents an attractive and potential therapeutic; a virtual Achilles’ heel.

Improvement of dendritic cell and NK-cell function by hyperthermia

Hsps and dendritic cell activation

The release of Hsps from tumor cells can serve as a potent activating signal for quiescent APCs. Accordingly, the ability to induce Dendritic Cell maturation seems directly proportional to the Hsp content of tumor cells. HSPs are able to mediate the cross-priming of tumor antigens. Cross-priming is the ability of extracellular Hsps complexed to tumor peptides to be internalized and presented in the context of MHC class I molecules on APCs, thus allowing potent priming of CTLs against tumor antigens. It has been reported that Hsps are generated from necrotic tumor cell lysates, but not from tumor cells undergoing apoptosis.

Necrotic tumor cell lysates enhance antigen cross-presentation more efficiently compared with early apoptotic tumor cells. Hyperthermia serves as a mediator of either tumor cell necrosis or apoptosis depending on the temperature used and the exposure time. Temperature, time and other factors associated with hyperthermia and cell killing have been comprehensively reviewed, and are likely to determine the mode of cell death. In tumor cells exposed to hyperthermia in the heat shock range (42°C for 4h) prior to lysing, DC activation and cross-priming were significantly enhanced with the application of heat. Enhanced cross-priming was directly attributed to increased expression of Hsps in hyperthermia-treated cells.

Conclusion

Insight into the mechanisms of hyperthermia and the influence of Hsps on the immune system has created a cornerstone for use in cancer treatment. A new emphasis on lymphocyte trafficking to lymphoid tissues, programming by DCs and chemoattraction to tumor sites are supported by the pleiotropic effects of hyperthermia. The use of hyperthermia as an adjuvant to existing immune therapy regimens represents a non-toxic, readily achievable treatment to reinvigorate marginally efficacious protocols for the treatment of cancer.

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Autologous Immune Enhancement Therapy

Bio-immune cellular therapy is the most advanced therapy of its kind. Throughout the extraction, manipulation and culture of specific linage of cells from the immune system (white blood cells) it is now possible to provide a high concentration of a particular cell line, such as Dendritic cells, NK cells, CD34. These cells improve, enhance, reinforce and balance the immune response needed to fight disease. Their proven uses array from autoimmune disorders, chronic infections, HIV to Cancer.

Cell based Immune-therapies are proven to be effective for cancers where the immune cells such as lymphocytes, macrophages, dendritic cells, natural killer cells (NK Cell), cytotoxic T lymphocytes (CTL), work together to defend the body against cancers and attacks by “foreign” or “non-self” invaders such as bacteria and viruses.

Cancer immunotherapy attempts to stimulate the immune system to reject and destroy tumors. In the beginning Immunotherapy treatments involved administration of cytokines such as Interleukin with an aim of inducing the lymphocytes to carry on their activity of destroying the tumor cells. This therapy lead to the extraction of the lymphocytes from the blood and culture-expanding them in the lab and then injecting the cells alone to enable them to destroy the cancer cells.

 Dendritic Cell Therapy

Dendritic Cell (DC) therapy represents a new and promising immunotherapeutic approach for treatment of advanced cancer as well as for secondary prevention of cancer. As Dr. Harmon Eyre, the VP of Research at the AMA commented on results of DC therapy for cancer: “Patients’ responses are far out of proportion to anything that any current therapy could do”.

For decades, cancer researchers have been interested in immunologic treatment using vaccines against cancer but with little progress, however, recent breakthroughs have shown that tumor-associated antigens can be used to vaccinate patients and that the dendritic cell is a potent blood cell able to present such antigens and stimulate the naïve immune system.

Dendritic Cell therapy has reported success even in stage IV cancer patients who have failed all other therapies.

Dendritic cells are professional antigen processing cells. They have a number of receptors that enhance the uptake of antigens, and they are specialized to convert these antigens into MHC-peptide complexes that can be recognized by lymphocytes. However, the dendritic cells need to do more than present antigens to T cells. They are also potent accessory cells that directly trigger and control responses by T cells and by all other types of lymphocytes.

Dendritic cells carry on their surface high levels of major histocompatibility complex (MHC) products, which are critically recognized by T-lymphocytes.

Dendritic cells are major stimulators and unusually potent. In fact, a dendritic cell to T cell ratio of 1 to 100 sufficed to initiate vigorous and optimal responses. Moreover, the dendritic cells directly activated both the subset of helper T cells as well as the killer T cells. Once activated by dendritic cells, the T cells could also interact vigorously with other antigen presenting B cells and macrophages to produce additional immune responses from these cells.

The term “accessory” has since been replaced by the terms “professional” and “co-stimulatory,” but the basic concept is unchanged. Dendritic cells provide the T cells with needed accessory or co-stimulatory substances, in addition to giving them a signal to begin to grow and function. For example, two of these specialized activities include the production of cytokines, like interleukin-12 and interferons, and the expression of a number of needed membrane molecules like CD40, CD70, and CD86.

Dendritic cells also influence the type or quality of the response. A T cell, for example, has to know whether the enemy is a virus that needs to be resisted with its own interferons and cytolytic molecules, or whether the pathogen is a malignant cell that requires a different set of protective cells to respond with. Therefore, when dendritic cells migrate to the body’s pool of T cells areas in the lymph nodes, they need to orchestrate two fundamental components from the repertoire of lymphocyte functions. First the dendritic cells select the rare specific T cells from the assembled repertoire that recognize the specific peptide information the dendritic cells are carrying. Amazingly, only one in 10,000-100,000 of the T cells in that repertoire are able to respond to this information. Second, the rare T cells that are selected for expansion then differentiate into helper and killer T cells that have the appropriate functions to eliminate the disease causing stimulus. After these two decisions have been made, the newly activated T cells leave the lymph node to return to the body surface or peripheral organ to eliminate the antigens. For orchestrating these various processes efficiently and precisely, the dendritic cells are considered to be “conductors of the immune orchestra”

Dendritic Cells and Immune Tolerance

Dendritic cells can also make the immune system tolerate harmless antigens, including those from the body’s own tissues, cells, and proteins. This is necessary to keep the body from making an immune attack on itself.

The dendritic cell system appears to play a pivotal role in two kinds of immune tolerance. Usually, when young T cells are launched from the thymus, the dendritic cells participate in eliminating those cells bearing “self-reactive antigens” before they can harm the body’s own tissues, a mechanism known as central tolerance.

Since some T cells may slip through this process, or other self-antigens do not access the thymus, or still others arise later in life, the dendritic cells also participate in the mechanism known as peripheral tolerance that restrains their activity. In the absence of infection or inflammation, the dendritic cells are in an immature state, but they are not quiescent. Like perpetual custodians, they clean house and collect trash. Sweeping non-stop through tissues and into lymphoid organs, the dendritic cells capture all kinds of antigens—the harmless self-antigens, those from dying cells, and the many nonpathogenic antigens encountered from the environment.

Two mechanisms have been identified that allow dendritic cells to induce tolerance. The antigen-loaded immature dendritic cells silence T cells by either deleting them or by inducing regulatory T cells that suppress the reactions of other immune cells. When the dendritic cells subsequently mature in response to threat, the preexisting tolerance nullifies any reaction to innocuous antigens and allows the dendritic cells to focus the immune response on the pathogen.

Dendritic cells and Cancer

Dendritic Cell approach to cancer therapy takes advantage of the normal role of the dendritic cell as an immune educator. Dendritic cells grab antigens from viruses, bacteria, or other organisms and wave them at T cells to recruit their help in an initial T cell immune response.

This works well against foreign cells that enter the body, but cancer cells often evade the self/non-self detection system.

By modifying dendritic cells, we are able to trigger a special kind of autoimmune response that includes a T cell attack of the cancer cells.

Because a cancer antigen alone is not enough to rally the immune troops, we first fuse a cytokine to a tumor antigen to send a strong antigenic signal.

Next, we grow patient’s dendritic cells in the incubator and let them take up this fused cytokine-tumor antigen. This enables the dendritic cells to mature and eventually display the same tumor antigens as appear on the patient’s cancer cells.

When these special mature dendritic cells are given back to the patient, they wave their newly acquired tumor antigens at the patient’s immune system, and those T cells that can respond mount an attack on the patient’s cancer cells.

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Natural Killer Cells

NK cells are a type of cytotoxic lymphocyte that constitutes a major component of the innate immune system. NK cells play a major role in the rejection of tumors and cells infected by viruses. They kill cells by releasing small cytoplasmic granules of proteins called perforin and granzyme that cause the target cell to die by apoptosis.

Natural killer (NK) cells have been at the forefront of immunology for two decades. During that time, a great amount of information about these cells has been obtained. They are important in anti-infectious and antitumor defense and shape the adaptive im mune response. In addition, they can act as immuno-regulatory cells. In recent years, the therapeutic potential of NK cells in cancer immunotherapy has become increasingly evident.
 

T-cell modulating therapy

Have you ever wondered how many components of your body and immune system know what to do and when to do it? 

When a bacterium, virus or fungus enters your body, dozens of immune system cells, molecules and body chemicals move into action and work to together to defeat the invader or kill a mutated cell that has become cancer. Once the battle with the pathogens is being won, this army of immune system components knows to quiet down and decrease activity. If they didn’t you could develop an autoimmune condition such as lupus, MS, type 1 diabetes, Crohn’s disease, rheumatoid arthritis or one of more than one hundred other autoimmune conditions.

Your immune system has smart cells or smart molecules that regulate all of this activity. One class of these smart peptides is called transfer factors. You have millions of transfer factors in your body right now. Without these regulators, your immune system would be chaotic and less effective.

Transfer factors move throughout the body in a soup or team of communication molecules. Transfer factors belong to a class of immune system molecules called cytokines. Cytokines are communication molecules. There is a great deal of communication taking place within your immune system coordinating its activities.

 Memory Molecules

Transfer factors also store information about the activities of your immune system. For example, when you had chicken pox as a child you didn’t develop this condition again. Why? Chicken pox germs enter your body off and on throughout your life. The reason you do not develop chicken pox again is that your immune system remembers the characteristics of the germ and how it was defeated.

This information is stored in a number of immune system components such as antibodies and transfer factors. Transfer factors are more sophisticated and have a broader range of influence than do antibodies.

When your body is attacked or cells mutate, transfer factors regulate a host of immune system components to move into the battle. Once the battle is over, there is a feedback function within the transfer factor soup that alerts the transfer factors that they need to down-regulate the activities.

Recognition and Modulation

Another benefit of the recognition properties of transfer factors is in the case of allergies. An agent that causes allergies should pass through your body without triggering an immune system response. When the recognition function of the immune system does not recognize the dust or pollen as an innocent factor, it attacks it and secretes histamine and other inflammatory agents.

Transfer factors assist the immune system in recognizing threats and then can up-regulate its activities or down-regulate its activities. They modulate the immune system. Transfer factors influence the activities of a great number of immune system components such as natural killer cells, T-killer cells, macrophages, monocytes, interferon, a number of interleukins, etc.

Some of these cytokines involved in inflammation are regulated by transfer factors. When your transfer factors do not recognize a problem, you get ill with such things as a cold, flu, infection, hepatitis, herpes, allergies, MS, rheumatoid arthritis, cancer, heart disease, Alzheimer’s and many other illnesses.

Due to stress, pollution, pesticides, poor diet, genetic factors, mutating germs, etc., your natural body transfer factors do not do the job that they were created to do. What is the difference between a person who develops cancer and one who doesn’t? What is the difference when one person in a family develops the flu but another doesn’t? Why do some people develop heart disease but others living almost exactly the same don’t? The difference is in the immune system.

Transfer Factors versus Regular Nutrients

Transfer factors work completely different in your body than nutrients. Each nutrient has a narrow range of function in the immune system. Nutrients can nourish immune system components, act as a catalyst and turn on certain receptors in immune system cells. Transfer factors regulate all of these immune system components. The influence of transfer factors on a particular immune system component is many times greater than any nutrient. Transfer factors, as smart cells, have feedback functions that nutrients do not have. Transfer factors actually enhance the efficiency of nutrients.

The History of Transfer Factors

From this discovery, research began its journey through the 1950s, 1960s, and 1970s. Scientists believed they had found that ultimate immune system and health enhancer. They believed that transfer factors would be the ultimate natural medicine. As technology increased, more and more was learned about the benefits of transfer factors.

More than 3500 studies were conducted and $40 million (USA) was invested into research. Scientists from more than 60 countries were involved in this research. Two developments stopped this progress. First was the development of antibiotics. Antibiotics were inexpensive to manufacture. They were effective. Antibiotics took the show.

Another development was the contamination of the world’s blood supply by HIV and hepatitis C virus. Up until this time, the only known source of transfer factors was derived from blood. Research stopped in its tracks.

In 1986, two hog scientists discovered that mothers passed down their transfer factors to their babies through the placenta and colostrum in order to give the baby’s immune system a chance to survive a hostile environment of pathogens. These scientists found the cows did the same thing. Often calves will not survive if for some reason they do not receive the colostrum from the mother.

Research began to move forward again. Antibiotics still reigned as king in the medical world. Many scientists that worked with transfer factors derived from blood didn’t think transfer factors from colostrum would work, so they didn’t enter the research.

Three events in history changed all of this. First, technology advanced. Secondly, germs began to become resistant to antibiotics. Thirdly, a large consumer database was derived from which a great deal of information about how transfer factors affected the health and immune systems of more than a million consumers. Now, research is exploding.

Transfer Factor’s Effect on the Human Immune System

 The latest breakthrough in the study of transfer factors was the discovery of small cytokines. Small cytokines are a complete new level of effectiveness and further distance itself from any known nutritional product in the world. Transfer factors created a complete new category of nutrient. Often you will read about a marketing company saying their product creates a new category of nutrient. This is a joke. There hasn’t been a new category of nutrition since herbs became well known in the western world. The introduction of antioxidants in the 1980’s came the closest to being a new category. Since then, there hasn’t been any discovery that would come close. Actually, when you consider how nutrients work, transfer factors are not even nutrients.

Transfer factors start a complete new category of agents that affect a person’s health. Transfer factors work through information and regulation.

Transfer factors with small cytokines are a complete new category of understanding. Small Cytokines are a doorway to a new world of scientific exploration. Most nutritional products have many other nutrients that can do similar things within a person’s body. For example, mangosteen can inhibit COX-2 but so can ginger root, turmeric, boswellia, etc. Nothing can come close to regulating the immune system and health like transfer factors. Transfer factors stand alone.

Transfer factors have the capacity to help millions of people’s health throughout the world and make a major difference in the lives of others. Individuals who have consumed transfer factors have experienced astounding results. No nutritional product has ever equaled the performance of transfer factors. Now, with the discovery of small cytokines, research on transfer factors will continue to produce new discoveries on its potential benefits.

Transfer factors naturally supports the body’s immune system, communicating immune information more efficiently among the cells in the body, and ultimately enhancing the body’s ability to withstand attacks on its health.

Our immune system protects us from germs, cancer and disease. Transfer factors modulate and educate the immune system. They can boost, strengthen, or suppress the immune system (in the case of autoimmune disease), but goes far beyond these effects. According to renowned medical specialists, transfer factors are the most significant breakthrough in the health care industry in this century.

ClinExpNeurol 1986; 22:149-154

 

Also, transfer factors contain inducers and suppressors that regulate the immune system’s response to disease. The inducers are used by the “brain” transfer factors to activate more “combat” cells into battle against germs and disease.

An independent test by Dr. Darryl See, found that transfer factors activate natural killer cells more than 100% more effectively than the body could without the boost. Enhanced transfer factors increased the activity of natural killer cells by 248%. Natural killer cells are your first line of defense against cancer, viruses, and bacteria. The suppressors are very important in maintaining your health. When germs enter the body or a mutated cell becomes cancerous, the transfer factor, which serves as the “brain” of the immune system, carefully guides the “combat” immune cells to the target and then activates the “combat” cells to destroy the target. After a successful battle, suppressor cells, through a biofeedback mechanism, remove the “combat” cells from the battle.

Sometimes immune cells overreact to an invader and destroy the battlefield, which is your body tissue. At times the immune system will actually target its own body as the enemy and attack it. This is called an autoimmune disorder. The transfer factor suppressor molecules are important in regulating the immune system so that you will not develop autoimmune disorders. There are hundreds of different autoimmune diseases.

Many people don’t even know that what they are suffering from is an autoimmune disease. Even allergies are a type of dysfunctional immune system that is attacking the wrong target.

Transfer Factor and Cancer

At this point we should explain that transfer factors are peptide chains composed of tens of amino acids that appear to store all the experience of the immune system. The great intellectual leap to understand is that transfer factors do not transfer antibodies nor create them directly but its function is to educate, and teach the immune cells to recognize specific antigens that could happen to them unnoticed i.e. malignant cells.

Transfer factors do not cure anything but work to make a “smarter” immune system so that it is the body itself eliminating disease. They are therefore vital in developing the strategies of the immune system against cancer.

Transfer Factors are immunomodulators in the sense that they do not force a global but specific and adequate response to malignant cells.

To understand its modus operandi, it can be said that transfer factors store ‘chemical photographs’ of the malignant cells in the body itself and transmit that information to the cells dedicated to combating the disease in the body where they are introduced.

Transfer Factor contains several immunoactive components that have been shown to act synergistically in raising Dendritic and NK function and also effective as adjuvant therapy in cancer treatments. In fact, one study has shown that Transfer Factor alone can raise Dendritic and NK function by nearly 250%.
 

Synergistic Cancer Suppression Treatments

 

Systemic Ozone Therapy 

Unlike healthy human cells that love oxygen, cancer cells are anaerobic, i.e. cannot live in high oxygen concentrations. Overexposure to oxygen in tumor cells, also known as the Hypothermic Ozonification, results in over-acidification of the heated cells and a consequent nutrient deficiency in the tumor Cellular metabolism is destroyed, resulting in apoptosis (dell death) of the tumor cells.

Cellular biologists have also detected that malignant cells have an increased rate of glycolysis, which increases the production of lactate.

Ozone therapy has the impact of significantly decreasing lactate production, indicating successful inhibition of the metabolism. Tumor cells suffer a peroxide intolerance due to insufficient peroxidase and catalase; ozone is thus able to oxidize the outer lipid layer of malignant cells and destroy them through cell lysis.

Laetrile Vitamin B17

Laetrile is natural and powerful anti-tumor agent found in over 1,200 plants, and is best known for its ability to prevent metastases without collateral damage to healthy normal cells.

Laetrile is particularly concentrated in the stones and seeds of common fruits such as apricots, peaches, plums and apples. It is a diglucoside with a cyanide radical that is highly “bio-accessible”, i.e., able to penetrate through the cellular membrane to reaching high intra-cellular concentrations.

Laetrile serves as glucose to healthy cells that provide energy when metabolized. Normal healthy cells contain an enzyme called rhodenase, which “neutralizes” the laetrile by preventing it from releasing cyanide. Malignant cells do not contain the rhodenase enzyme; in the absence of rhodenase, cyanide radical is released within malignant cells when laetrile is activated, resulting in tumor destruction.

Laetrile has been scientifically demonstrated to be non-toxic; our own experience with thousands of patients gives us complete confidence that this natural agent poses no danger in treatment.

Cancer cells contain thousands of times more of the enzyme beta-glucosidase than noncancerous cells.

When Laetrile interacts with beta-glucosidase, it breaks down into its component structures:

  • Two molecules of glucose, a sugar
  • One molecule of benzaldehyde, an analgesic (pain-relieving drug)
  • One molecule of hydrocyanic acid, a poison

The pharmacological equation might be expressed like this: beta-glucosidase + laetrile = toxic cyanide that is naturally targeted/isolated to cancerous cells. Additionally, the Laetrile/beta-glucosidase reaction triggers the release of the Benzaldehyde, a known analgesic.

Laetrile is effective in reducing tumor related pain and increasing the survivability of late stage critical patients. It is best known for its ability to prevent metastases in all types of cancers.

As early as 1974, Laetrile was being used intravenously at levels of six to nine thousand milligrams daily (i.e. six to nine grams). In general, an accumulation of fifty to seventy grams of Laetrile over a period of seven to ten days is needed before patients experience tangible improvement.

Through treatment of hundreds of patients, the Angeles Functional Oncology team has identified found the most impactful method of Laetrile treatment is six grams, intravenously delivered once per day over a period of three weeks. Although Laetrile can be administered orally, the not uncommon presence of intestinal bacteria can result in small amounts of cyanide production, necessitating that oral doses be limited to three grams or less per day (and therefore a longer program of accumulating treatment effect).

 IV Vitamin C

Research investigators at the National Institute of Health report that the anticancer mechanism responsible for Vitamin C involves production of hydrogen peroxide, which is selectively toxic to cancer cells.

Vitamin C is vital in the protection of certain indispensable molecules in the body such as proteins, lipids (fats), carbohydrates, and nucleic acids (DNA and RNA), from damage by free radicals and reactive oxygen species that can be generated during normal metabolism as well as through exposure to environmental toxins and pollutants such as pollution and cigarette smoke.

Increased Vitamin C consumption is associated with reduced risk for most types of cancer. Multiple case-control studies have investigated the role of Vitamin C in cancer prevention, and most have shown that higher intakes of Vitamin C are associated with decreased incidence of cancers of the mouth, throat and vocal chords, esophagus, stomach, colon-rectum, and lung. One study that followed 870 men over a period of 25 years found that those who consumed more than 83 mg. of Vitamin C daily experienced a striking 64% reduction in lung cancer compared with those who consumed less than 63 mg. per day.

Vitamin C inhibits the formation of carcinogenic compounds in the stomach, a finding supported in observational studies that have found increased dietary Vitamin C intake to be associated with decreased risk of stomach cancer.

Studies conducted by Linus Pauling (Nobel Prize winning scientist, pioneer in the fields of quantum chemistry, molecular biology, and orthomolecular medicine) suggest that very large doses of Vitamin C (10 grams/day intravenously for ten days followed by at least 10 grams/day orally indefinitely) are helpful in increasing the survival time and improving the quality of life of terminal cancer patients.

Intravenous (IV) administration of Vitamin C result in much higher blood levels of Vitamin C than oral administration, and Vitamin C levels that are toxic to cancer cells in culture can be achieved in humans only with intravenous but not oral administration of Vitamin C. The Angeles Functional Oncology treatment program provides IV-delivery of Vitamin C in concentrated dosage, ranging from 40 to 70 grams per day.

Selenium

Laboratory studies show selenium is a powerful antioxidant that can inhibit the growth of breast, cervical, colon, and skin cancer, promotes cancer cell death (apoptosis), acts as a protective agent against many types of cancers, and improves quality of life during aggressive cancer therapies.

Most American diets include only a fraction of the recommended dose of 200 micrograms a day; Disease and Treatment by the Life Extension Foundation estimates most Americans get as little as 60 to 100 micrograms of selenium daily.

Taken in conjunction with Vitamins C, E and beta-carotene, selenium works to block the chemical reactions that create DNA-damaging free radicals responsible for the cell degeneration that leads to cancer. Selenium contributes to cell death of cancerous and pre-cancer cells, plus prevents the reproduction of damaged DNA molecules which in turn inhibits tumor development and formation, In short, evidence suggests that selenium is a mineral essential to helping stop cancer before it gets started.

The protective effective of selenium can be accounted for in several ways. Selenium inhibits the formation of DNA-damaging free radicals through the activation of the enzyme gluthathione peroxidas. In addition, selenium, in concert with Vitamin E, inhibits tumor growth while regulating cell lifespan, a function that inhibits the ability of cells to become immortal i.e. malignant.

Some forms of cancer are the result of free radical oxidation that destroys or damages the part of the DNA that regulates cell multiplication. When this happens, abnormal cell proliferation can quite literally invade the entire body, damaging healthy tissue. For patients who have been diagnosed with cancer, selenium may be useful in slowing this progression.

Melatonin.

Melatonin can kill directly many different types of human tumor cells. It is a naturally produced cytotoxin, which can induce tumor cell death (apoptosis). In instances where the tumor has already established itself in the body, melatonin has been shown to inhibit the tumor’s growth rate. Melatonin exhibits natural oncostatic activity and inhibits cancer cell growth. In patients in whom cancer already has become a noticeable physical burden and produces overt symptoms, melatonin has been shown to alleviate numerous cancer symptoms and to inhibit development of new tumor blood vessels (tumor angiogenesis), which in turn inhibits the cancer from spreading further (metastasis). Furthermore, as an inducer of antioxidants and itself a weak preventive antioxidant, melatonin hinders tumor cells from participating in free radical damage to normal cells and consequently limits oxidative damage to DNA, lipids, amino acids, and proteins.